Biologically interpretable machine learning modeling for understanding functional genomics
Robust phenotype-genotype associations have been established for a number of human diseases including brain disorders (e.g., schizophrenia, bipolar disorder). However, understanding the cellular and molecular causes from genotype to phenotype remains elusive. To address this, recent scientific projects have generated large multi-omic datasets — e.g., the PsychENCODE consortium generated ~5,500 genotype, …